Know thy enemy: Resolving the SARS-CoV-2 gene set and understanding COVID-19 variants using evolution
Can comparative genomics resolve the protein-coding gene set of SARS-CoV-2? Yes! We compared 44 Sarbecovirus genomes to determine which SARS-CoV-2 candidate genes encode functional proteins and which mutations are likely functional, so future efforts can focus on real genes and important mutations.
