Individuals who have the ability to control HIV-1 to undetectable levels either naturally in the absence of antiretroviral treatment (ART) (elite controllers), or those who achieve this after starting ART early in infection and later stopping ART (post-treatment controllers) – tell us that HIV remission is possible. This study describes virological and immunological features associated with a single case of durable post-treatment control of HIV-1 in a young South African child.