Stereochemical Trajectories of a Two-Component Regulatory System PmrA/B in a Colistin-Resistant Acinetobacter baumannii Clinical Isolate

A few details exist on Acinetobacter baumannii two-component system PmrA/B protein geometry and amino acids substitutions in domains involved i in strains showing high MIC to colistin.

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We carried out an in silico analysis of both PmrA/B proteins including stereochemical structures domains activity amino acids involved and molecular ducking of colistin to these proteins. We found certain amino acids substitutions in certain locations od LPXACD and PmrB  play an important role in emergence of colistin resistant isolates of A. baumannii exhibiting high MIC value toward colistin  

Mohammad Reza Shakibaie

Professor and senior research scientist in microbiology, Department of Microbiology and Virology, Kerman University of Medical Sciences, Kerman, Iran

I earned my Ph.D. from the University of Pune India from 1992 to 1997. His thesis was "Molecular genetics of plasmid-mediated silver and antibiotic resistances in Acinetobacter baumannii”. I completed one year of postdoctoral research training at Aquatic Microbial Lab in Mysore, India in 2006. The title of my Postdoc research was "Horizontal Gene Transfer in Gram-Negative Bacteria". I joined the Department of Microbiology, Kerman University of Medical Sciences in 1998. I published more than 45 original research papers in different International peer-reviewed journals with high impact factors in microbiology and biotechnology. The total impact factor of his research is more than 86, with h-index 13 and i10-index 27. The research gate score index is 27.85. My works also have been cited in 3 textbooks of microbiology published from the USA and Europe. I presented more than 42 papers at International and National Conferences. He has made fundamental contributions in the area of gene transfer, plasmid biology, molecular microbiology, nanotechnology.  I successfully supervised 4 Ph.D. and 1 Post-Doctoral scholar for their research. Currently, 2 Ph.D. students are working with me. Recently, we published a paper in Iran Biomed J 2021 May 1;25(3):193-201. DOI: 10.29252/ibj.25.3.157 entitled Seterochemical Trajectories of PmrA/B Two-component regulatory system in Colistin Resistant Clinical isolates of Acinetobacter baumannii