July 2017 cover

Linear ubiquitin recruitment to Salmonella mediates xenophagy and immune signaling. Image by Ella Maru Studio; cover design by Karen Moore.

Published Aug 02, 2017

Michael Chao

Project Manager, Harvard TH Chan School of Public Health

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Sending signals

Linear polyubiquitin patches in the Salmonella Typhimurium ubiquitin coat, regulated by E3 ligase LUBAC and deubiquitinase OTULIN, serve as a platform to modulate xenophagy, NF-kB signalling, secretion of pro-inflammatory cytokines and bacterial proliferation.

Refers to "Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation" by van Wijk et al.

and

"LUBAC-synthesized linear ubiquitin chains restrict cytosol-invading bacteria by activating autophagy and NF-κB" by Noad et al.

Nature Microbiology 2: 17066 (2017)

Nature Microbiology 2: 17063 (2017)

Michael Chao

Project Manager, Harvard TH Chan School of Public Health

I first developed an interest in bacterial pathogenesis while at Cornell University. I then earned my PhD in Biomedical and Biological Sciences from Harvard University in Eric Rubin’s laboratory, studying cell wall remodelling in Mycobacterium tuberculosis. From 2012-2015, I continued my training as a postdoctoral fellow in Matthew Waldor’s lab at Harvard Medical School, investigating the role of DNA methylation on regulating fundamental cellular processes in Vibrio cholerae.