Linear polyubiquitin patches in the Salmonella Typhimurium ubiquitin coat, regulated by E3 ligase LUBAC and deubiquitinase OTULIN, serve as a platform to modulate xenophagy, NF-kB signalling, secretion of pro-inflammatory cytokines and bacterial proliferation.
Refers to "Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation" by van Wijk et al.
"LUBAC-synthesized linear ubiquitin chains restrict cytosol-invading bacteria by activating autophagy and NF-κB" by Noad et al.
Nature Microbiology 2: 17066 (2017)
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