June 2017 cover

Structural analysis of the mycobacterial ESX-5 type VII secretion system. Image by Tobias Wüstefeld; cover design by Samantha Whitham.

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Single-particle analysis of cryo-electron microscopy structures elucidates the membrane complex of the mycobacterial ESX-5 type VII secretion system. This secretion pathway is used to deliver virulence factors from the bacterial cytoplasm into the host cell through a channel in the bacterial inner membrane. 

Refers to "Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis" by Beckham et al.

Nature Microbiology 2: 17047 (2017)

Michael Chao

Project Manager, Harvard TH Chan School of Public Health

I first developed an interest in bacterial pathogenesis while at Cornell University. I then earned my PhD in Biomedical and Biological Sciences from Harvard University in Eric Rubin’s laboratory, studying cell wall remodelling in Mycobacterium tuberculosis. From 2012-2015, I continued my training as a postdoctoral fellow in Matthew Waldor’s lab at Harvard Medical School, investigating the role of DNA methylation on regulating fundamental cellular processes in Vibrio cholerae.