May 2017 cover

Malaria parasite cell-cycle kinase CRK4 directs continuous DNA replication during schizogony. Image by Markus Ganter; cover design by Samantha Whitham.
May 2017 cover

Cycle proficiency

In the pathogenic blood stage of infection, Plasmodium falciparum cell-cycle progression is directed by the parasite-specific kinase CRK4. Without active CRK4, DNA replication is inhibited and the nuclei are deformed by spindle-like structures.

Refers to "Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony" by Ganter et al.

Nature Microbiology 2: 17017 (2017)

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