January 2017 cover
Imprinting on infection. E. coli infection leads to urothelial remodeling. Image by Valerie P. O'Brien, Matthew Joens, Jaclynn Lett, James A. Fitzpatrick & Scott J. Hultgren.
Previous infection with Escherichia coli epigenetically alters host epithelial cell maturation and COX-2-mediated inflammation to predispose mice for future recurrent infection.
Refers to "A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease" by O'Brien et al.
Nature Microbiology 2: 16196 (2016)