January 2017 cover

Imprinting on infection. E. coli infection leads to urothelial remodeling. Image by Valerie P. O'Brien, Matthew Joens, Jaclynn Lett, James A. Fitzpatrick & Scott J. Hultgren.

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Previous infection with Escherichia coli epigenetically alters host epithelial cell maturation and COX-2-mediated inflammation to predispose mice for future recurrent infection.

Refers to "A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease" by O'Brien et al.

Nature Microbiology 2: 16196 (2016)

Michael Chao

Project Manager, Harvard TH Chan School of Public Health

I first developed an interest in bacterial pathogenesis while at Cornell University. I then earned my PhD in Biomedical and Biological Sciences from Harvard University in Eric Rubin’s laboratory, studying cell wall remodelling in Mycobacterium tuberculosis. From 2012-2015, I continued my training as a postdoctoral fellow in Matthew Waldor’s lab at Harvard Medical School, investigating the role of DNA methylation on regulating fundamental cellular processes in Vibrio cholerae.