New Clinical Practice Guidelines on Diagnosis of Tuberculosis in Adults and Children

Today, ATS, CDC and IDSA published their official clinical guideline on TB diagnosis.

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Diagnosis remains one of the weakest links in tuberculosis care and control. Today, a new guideline was published in Clinical Infectious Diseases. A task force, to which I contributed, supported by the American Thoracic Society, Centers for Disease Control and Prevention, and Infectious Diseases Society of America searched, selected, and synthesized relevant evidence. The evidence was then used as the basis for recommendations about the diagnosis of tuberculosis disease and latent TB infection (LTBI) in adults and children. The recommendations were formulated, written, and graded using the GRADE approach. 23 evidence-based recommendations about diagnostic testing for latent tuberculosis infection, pulmonary tuberculosis, and extrapulmonary tuberculosis are provided. Six of the recommendations are strong, whereas the remaining 17 are conditional.

As an example, the figure below shows the recommendations on testing for latent TB infection.

The guideline also provides several recommendations on tests for active TB disease.

Full text of the guideline can be downloaded at:

Madhukar Pai

Associate Director, McGill International TB Centre

I am a Professor and a Canada Research Chair in Epidemiology & Global Health at McGill University, Montreal. I serve as the Associate Director of the McGill International TB Centre. URL: