Clostridium difficile sporulation: roles of an essential protein complex

In this paper in Molecular Microbiology, we describe our results that show that SpoIIQ and SpoIIIAH form a complex in C. difficile. This complex is essential for forespore engulfment and, surprisingly, also seems to be required for late stages of spore morphogenesis and gene expression control. This work highlights key differences between C. difficile and the model Gram-positive bacterium Bacillus subtilis, paving the way to a better understanding of sporulation mechanisms in C. difficile.

Please sign in or register for FREE

If you are a registered user on Microbiology Community, please sign in