Clostridium difficile sporulation: roles of an essential protein complex

In this paper in Molecular Microbiology, we describe our results that show that SpoIIQ and SpoIIIAH form a complex in C. difficile. This complex is essential for forespore engulfment and, surprisingly, also seems to be required for late stages of spore morphogenesis and gene expression control. This work highlights key differences between C. difficile and the model Gram-positive bacterium Bacillus subtilis, paving the way to a better understanding of sporulation mechanisms in C. difficile.

Like Comment

Paula S. Salgado

Lecturer in Macromolecular Crystallography at Newcastle University, Newcastle University

My main research aims at understanding the molecular details of pathogenicity in bacteria. I have a particular interest in Clostridium difficile, a major cause of hospital-acquired infections strongly associated with antibiotic usage and resistance. Currently, we focus on surface proteins and sporulation mechanisms in C. difficile.