The condensation enzyme CcbD catalyzes an amide bond formation between the carrier protein-tethered proline and thiooctose in the biosynthesis of lincosamide antibiotics. Here, we report the structure-function analyses of CcbD by in vitro characterization, crystallization, and mutagenesis.
Greenhouse gas emissions from natural gas pipeline incidents
Our research consortium conducted a study quantifying GHG emissions from natural gas pipeline incidents in the United States and Canada from the 1980s to 2021, using Monte Carlo simulation methods.
Importance of Pacific oceanic front for the North Atlantic blocking
Recent studies have examined the local impact of the Gulf Stream front on North Atlantic blocking. In this study we used semi-idealized atmospheric-only experiments to identify the additional crucial role of the Kuroshio Extension front in setting the climatological North Atlantic blocking activity.