Integrating Somatic CNV and Gene Expression in Breast Cancers from Women with PTEN Hamartoma Tumor Syndrome
Copy number variation and transcript features from breast cancers arising in the setting of germline PTEN mutations revealed distinct biological characteristics compared to sporadic breast cancers.
Niche heterogeneity influences the outcomes in myeloproliferative neoplasms
The reasons underlying the different pathogenesis and response to therapies in the myeloproliferative neoplasms have remained enigmatic. Grockowiak et al. provide some clues emerging from disease-specific alterations in the interaction of hematopoietic stem cells with their bone marrow niches (1).