Niche heterogeneity influences the outcomes in myeloproliferative neoplasms
The reasons underlying the different pathogenesis and response to therapies in the myeloproliferative neoplasms have remained enigmatic. Grockowiak et al. provide some clues emerging from disease-specific alterations in the interaction of hematopoietic stem cells with their bone marrow niches (1).
Unveiling the Intricate Dance of HSP90: A Master Conductor of Cellular Responses in Health and Disease
In the intricate world of cellular responses, a molecular maestro plays a pivotal role – HSP90. What makes HSP90 truly fascinating is its conformational flexibility. Scientists are now uncovering the profound impact of HSP90's conformational changes on cellular responses in health and disease.
An atlas showing the genetic modifications occurring in all dental pulp cell populations upon carious insult in human teeth
The recent Editor’s Choice article published in the International Journal of Oral Science provides the first comprehensive single-cell atlas of dental caries. The study provides an unprecedented view of molecular and cellular changes occurring in the tooth dental pulp upon carious lesion