Discovery of a natural IgA human monoclonal antibody against Mtb protein LpqH and its significance in TB prophylaxis

The discovery of a protective natural IgA human monoclonal antibody against LpqH, a major virulence factor in Mtb pathogenesis, from a naturally exposed asymptomatic donor, opens new avenues in TB vaccine development and prophylaxis.

Shivankari Krishnananthasivam, Ph.D

Aug 26, 2023

npj Vaccines

Behind the paper

Full-length MSP1 as a malaria vaccine: is there hope?

Successful immunisation studies in monkeys based on MSP1 involved the use of the full-length protein as a malaria vaccine. However, unsuccessful human trials only tested MSP1 subunits. We explore the potential of SumayaVac-1 to broadly stimulate immune mechanisms associated with protection.

Richard Thomson Luque

Aug 22, 2023

Microbiology Community

npj Vaccines

Discovery of a natural IgA human monoclonal antibody against Mtb protein LpqH and its significance in TB prophylaxis

Full-length MSP1 as a malaria vaccine: is there hope?

Behind Promising Cryptococcal Vaccines

T cells, but not nAbs, mediate immunity to the omicron variant of SARS-CoV-2

Raising the standard for Zika

Fortifying gastric defences against Helicobacter pylori

Redirecting an ineffective natural immune response to achieve biofilm eradication

Double may be less

What are we missing? Comparing the immunoproteomes of enterotoxigenic E. coli infected and vaccinated hosts can yield insights for rational vaccine design.

npj Vaccines

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