Cyclic di-GMP transduces extracellular stimuli into intracellular responses to modulate important biological processes. Little is known about how extracellular signals modulate c-di-GMP metabolism to control T3SSs. Here is the answer.
H37Rv is the most widely used M. tuberculosis strain, and its genome is the reference sequence for this pathogen. Chitale et al. presents a bioinformatic pipeline for accurate assembly of bacterial genome sequences, and use it to provide important updates to the M. tuberculosis reference genome.
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