Nature Comms
Global biomarkers of sepsis-causing bacteria investigated through the lens of multi-omic approaches
Bringing together some of Australia’s leading biomedical microbiologists and bioinformaticians to develop a reference bacterial sepsis dataset.
Lipopolysaccharide biosynthesis is spatially organized in the pathogen Brucella abortus
In Gram-negative bacteria, newly made lipopolysaccharide (LPS) is exported to the outer membrane. We report where key steps in the LPS biosynthesis occur in the asymmetric bacterium Brucella abortus. Moreover, we discovered an enzyme with two activities allowing it to complete LPS biosynthesis.
The infection event could have ended in tragedy
We present the scientific story we discovered (https://www.nature.com/articles/s41467-023-36123-w) in the form of a drama.
Reactive Metal Boride Nanoparticles Trap Lipopolysaccharide and Peptidoglycan for Bacteria-Infected Wound Healing
Antibacterial wound healing approaches often target bacteria but overlook the inflammation response caused by products released by dead bacteria. The authors develop MB nanoparticles to prevent both infection and excessive inflammation by trapping the key component of bacteria, LPS/PGN.
Cyclic di-GMP is central to the function of T3SSs
Cyclic di-GMP transduces extracellular stimuli into intracellular responses to modulate important biological processes. Little is known about how extracellular signals modulate c-di-GMP metabolism to control T3SSs. Here is the answer.
