Nature
A weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions.
The membrane-active polyaminoisoprenyl compound NV716 re-sensitizes Pseudomonas aeruginosa to antibiotics and reduces bacterial virulence
Infections caused by Pseudomonas aeruginosa are difficult to threat for many reasons. Among them, P. aeruginosa shows intrinsic or acquired resistance to several antibiotics. It expresses virulence factors and adopts specific lifestyles, like biofilms, non-responsive to antibiotics.
Complete shut-down
How SARS-CoV-2 shuts down host gene expression and takes over the cellular translation machinery.
Dysbiosis discovered in plants
Most of us are familiar with the term “Inflammatory Bowel Disease (IBD)”. However, you likely have not heard about “Inflammatory Phyllosphere Disease (IPD)”. This is because I have just made it up to draw your attention, and to describe a form of dysbiosis in plants that we have just reported.
Autophagy mediates evasion of bacterial missiles by mediating the release of decoy flares
Many disease-causing bacteria secrete pore-forming toxins that target the plasma membrane of host cells. We uncovered a counter defence response by the host involving the release of extracellular vesicles, defensosomes, downstream of innate immune activation of autophagy proteins.
